Korean J Anesthesiol.  1998 Jan;34(1):132-136. 10.4097/kjae.1998.34.1.132.

Influence of Droperidol on Postoperative Nausea and Vomiting during Patient-Controlled Analgesia with Fentanyl

• Park SM
• Kim SI
• Park W

• KMID: 2032355
• DOI: http://doi.org/10.4097/kjae.1998.34.1.132

Abstract

INTRODUCTION
Patient-controlled analgesia (PCA) has become an important means for postoperative analgesia with parenteral opioid, but postoperative nausea and vomiting (PONV) remains a major problem using a PCA system. The present study was designed to assess the antiemetic effectiveness of droperidol in patients using an intravenous PCA during the first 24 hours after surgery.
METHODS
For the postoperative analgesia, 80 patients underwent orthopedic surgery were randomly allocated to receive PCA with either a mixture of 3.75 mg droperidol and fentanyl 2500 microgram after initial bolus of 1.25 mg droperidol as the FD group, or a mixture of saline and fentanyl 2500 microgram as the FS group at the end of surgery.
RESULTS
The incidence of PONV showed 52.5% in FS group and 15% in FD group respectively (P<0.05). The incidence of PONV was 2~3 times more in women (76% in FS group & 25% in FD group) than men (35% in FS group & 9% in FD group).
CONCLUSION
The addition of droperidol to fentanyl in a PCA system reduces the PONV during the first 24 hours after surgery.

Keyword

Analgesics: intravenous; fentanyl; Pharmacology: droperidol; Vomiting: nausea; postoperative

MeSH Terms

Analgesia
Analgesia, Patient-Controlled*
Antiemetics
Droperidol*
Female
Fentanyl*
Humans
Incidence
Male
Orthopedics
Passive Cutaneous Anaphylaxis
Postoperative Nausea and Vomiting*
Antiemetics
Droperidol
Fentanyl