Korean J Anesthesiol.  1997 Dec;33(6):1164-1169. 10.4097/kjae.1997.33.6.1164.

Comparison of Ondansetron and Droperidol in Reducing Postoperative Nausea and Sedation Associated with Patient-Controlled Analgesia

• Kim JA
• Do SH
• Ko H
• Lee SA

• KMID: 2299265
• DOI: http://doi.org/10.4097/kjae.1997.33.6.1164

Abstract

BACKGROUND: To know the effect of droperidol and ondansetron on nausea and sedation in postoperative patients, we studied 120 gynecological patients receiving patient-controlled analgesia (PCA) with morphine and droperidol or ondansetron.
METHODS
Subjects were randomly allocated to one of four groups according to PCA regimen, morphine 0.5 mg/cc alone (group M); morphine plus droperidol 0.034 mg/morphine 1 mg (group D); morphine plus ondansetron 0.132 mg/morphine 1 mg (group O1); morphine plus ondansetron 0.066 mg/morphine 1 mg (group O2). The PCA device, WalkMed was set at basal rate 2 ml/hr (1 mg/hr), bolus dose 1 ml (0.5 mg), lockout time 10min, 1 hour maximum dose 4 mg. The severity of nausea, sedation and pain were assessed at 1h, 4h, 8h, 12h, 24h, and 48h postoperatively.
RESULTS
The occurrence of nausea was not different among groups. But there were statistical differences in the nausea severity (p<0.05). The group D and group O1 had lower nausea scores, and between them there was no difference. The scores for sedation were significantly lower in the group O1 compared with group M and group D (p<0.05). Overall pain scores were not different among groups.
CONCLUSIONS
Ondansetron and droperidol are effective in reducing nausea. Ondansetron is superior to droperidol in avoiding excessive sedation.

Keyword

Analgesia, patient-controlled (PCA); Analgesics, morphine; Complication, sedation, nausea

MeSH Terms

Analgesia, Patient-Controlled*
Droperidol*
Humans
Morphine
Nausea
Ondansetron*
Passive Cutaneous Anaphylaxis
Postoperative Nausea and Vomiting*
Droperidol
Morphine
Ondansetron