Korean J Anesthesiol.  1998 Sep;35(3):518-522. 10.4097/kjae.1998.35.3.518.

The Comparison of Effectiveness of Ondansetron and Droperidol on Antiemesis

• Kim DH
• Lee SY
• Park CH

• KMID: 2240141
• DOI: http://doi.org/10.4097/kjae.1998.35.3.518

Abstract

BACKGROUND
This study was designed to compare the efficacy and safety of ondansetron with droperidol in the prevention of postoperative nausea and vomiting (PONV) using intravenous patient-controlled analgesia (IV-PCA).
METHODS
Sixty women were randomly allocated to one of four groups after total abdominal hysterectomy under general anesthesia, droperidol 1 mg (Group 1), 2 mg (Group 2), ondansetron 2 mg (Group 3), 4 mg (Group 4) bolus injection with butorphanol 1 mg and added the same drug to PCA drug (butorphanol 10 mg). The severity of pain, nausea, vomiting and sedation were assessed at 0, 1, 2, 6, 12, 24, 36 and 48hr postoperatively.
RESULTS
The occurrence of nausea and vomiting was significantly higher in Group 1, 2 than Group 4. The sedation score and incidence of dizziness were significantly higher in Group 1, 2 than Group 3, 4.
CONCLUSIONS
The addition of ondansetron to PCA drug is more effective and safe in the prevention of postoperative nausea and vomiting and has less sedation and dizziness effect than droperidol. But, droperidol has a cost-saving effect.

Keyword

Analgesia: Patient-controlled (PCA); Antiemetics: droperidol; ondansetron; Complication: nausea

MeSH Terms

Analgesia, Patient-Controlled
Anesthesia, General
Butorphanol
Dizziness
Droperidol*
Female
Humans
Hysterectomy
Incidence
Nausea
Ondansetron*
Passive Cutaneous Anaphylaxis
Postoperative Nausea and Vomiting
Vomiting
Butorphanol
Droperidol
Ondansetron