Korean J Anesthesiol.  1999 Mar;36(3):402-406. 10.4097/kjae.1999.36.3.402.

Effect of Propofol on the Incidence of Postoperative Nausea and Vomiting after Minor Orthopedic Surgery

• Kim SI
• Kim SC

• KMID: 2032280
• DOI: http://doi.org/10.4097/kjae.1999.36.3.402

Abstract

BACKGROUND: The aim of the present study is to evaluate the effect of propofol on the incidence of postoperative nausea and vomiting (PONV) during the first 24 hours after minor orthopedic surgery using general anesthesia.
METHODS
We studied 66 healthy female patients (aged 20-67 years old). The patients were randomly divided into the two groups: (i) Group P (n=33): Anesthesia was induced with propofol and fentanyl, and maintained with continuous infusion of propofol. (ii) Group E (n=33): Anesthesia was induced with thiopental and fentanyl, and maintained with enflurane. We compared the incidence and severity of PONV at 6 and 24 hours after the operation between the two groups.
RESULTS
The incidence and severity of PONV in Group P was significantly lower than in Group E during the first 6 hours after the operation (p<0.05). However, after 6 hours, there was no significant differences between the two groups.
CONCLUSION
In the early postoperative period, the use of propofol prevents PONV.

Keyword

Anesthetics, intravenous, propofol; Vomiting, nausea, postoperative

MeSH Terms

Anesthesia
Anesthesia, General
Enflurane
Female
Fentanyl
Humans
Incidence*
Orthopedics*
Postoperative Nausea and Vomiting*
Postoperative Period
Propofol*
Thiopental
Enflurane
Fentanyl
Propofol
Thiopental