Korean J Anesthesiol.  2000 Nov;39(5):662-666. 10.4097/kjae.2000.39.5.662.

The Effect of Isoflurane or Propofol on Hepatic Transaminase in Healthy Hepatitis B Carrier Patients

• Kim SC
• Bae DK
• Kim CS
• Kim SI

• KMID: 2031634
• DOI: http://doi.org/10.4097/kjae.2000.39.5.662

Abstract

BACKGROUND: Isoflurane or propofol has been known to have a low potential for hepatotoxicity. The purpose of this study is to evaluate the effect of isoflurane or propofol on hepatic transaminase in healthy hepatitis B carrier patients. METHODS: Forty-six patients who were healthy hepatitis B carriers were studied following an orthopedic surgery. The patients were randomly assigned to Group I (n = 22) who received isoflurane, or group P (n = 24) who received propofol. The plasma concentrations of aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured on the day before the operation, and 1, 3, and 7 days after the operation. RESULTS: The plasma concentrations of AST were not changed significantly until the 7th day post-operatively in both groups, and there were no significant differences between the two groups. The plasma concentrations of ALT were significantly decreased at 1 and 3 days postoperatively (P < 0.05) in both groups. However, it recovered to baseline concentrations at 7 days postoperatively. There were no significant differences between the two groups. CONCLSIONS: The use of isoflurane or propofol does not increase the plasma concentrations of hepatic transaminase in Hepatitis B carrier patients after an operation.

Keyword

Anesthetics, intravenous: propofol; Anesthetics, volatile: isoflurane; Infection: hepatic; hepatitis B carrier; Liver: function; transaminase

MeSH Terms

Alanine Transaminase
Aspartate Aminotransferases
Hepatitis B*
Hepatitis*
Humans
Isoflurane*
Orthopedics
Plasma
Propofol*
Alanine Transaminase
Aspartate Aminotransferases
Isoflurane
Propofol