Korean J Anesthesiol.  1999 Dec;37(6):1095-1100. 10.4097/kjae.1999.37.6.1095.

The Postoperative Antiemetic Effect of Midazolam in Patients Undergoing Appendectomy

• Cho SY
• Oh MK
• Yeom JH
• Shin WJ
• Kim YC
• Lee DH

• KMID: 2031462
• DOI: http://doi.org/10.4097/kjae.1999.37.6.1095

Abstract

BACKGROUND: Postoperative nausea and vomiting are common postoperative complaints. The purpose of this study was to assess the effect of preoperative midazolam on vomiting after appendectomy.
METHODS
Sixty patients, aged 10 64 yr, undergoing emergency appendectomy were randomly allocated to receive midazolam 30, 50, 75 microgram/kg or placebo after induction of anesthesia. Anesthesia consisted of 67% nitrous oxide, 33% oxygen and propofol infusion 6 10 mg/kg/h. Postoperative vomiting was checked by the recovery room nurse at 1 h after operation and we examined the incidence of postoperative vomiting at 24 h after operation.
RESULTS
Midazolam reduced the overall incidence of vomiting, especially in the midazolam 50 and 75 microgram/kg groups, completely abolishing vomiting (P< 0.05). However, in the midazolam 75 microgram/kg group, there was a delay in eye opening time (P< 0.05).
CONCLUSIONS
Preoperative injections of midazolam 30 or 50 microgram/kg were useful to prevent postoperative vomiting in patients undergoing appendectomy without delayed recovery.

Keyword

Anesthetics, intravenous, propofol; Antiemetics, midazolam; Complication, vomiting; Surgery, appendectomy

MeSH Terms

Anesthesia
Antiemetics*
Appendectomy*
Emergencies
Humans
Incidence
Midazolam*
Nitrous Oxide
Oxygen
Postoperative Nausea and Vomiting
Propofol
Recovery Room
Vomiting
Antiemetics
Midazolam
Nitrous Oxide
Oxygen
Propofol