Korean J Anesthesiol.  2007 May;52(5):550-555. 10.4097/kjae.2007.52.5.550.

Effect of Midazolam upon the Prevention of Nausea and Vomiting after Middle Ear Surgery

• Jung JS
• Jeon YH

• KMID: 2239873
• DOI: http://doi.org/10.4097/kjae.2007.52.5.550

Abstract

BACKGROUND: Midazolam has been reported to decrease postoperative nausea and vomiting (PONV). We studied the antiemetic effect of midazolam after middle ear surgery.
METHODS
In this prospective, randomized, double-blind, placebo-controlled study, 90 healthy patients were scheduled for middle ear surgery (tympanomastoidectomy and tympanoplasty). Patients were randomly divided into two groups; Midazolam 0.075 mg/kg (n = 45) or normal saline (n = 45) was administered after induction of anesthesia. The incidence of PONV, metoclopramide and ketorolac usage, pain, sedation, and other side effects were assessed at 6, 24 h after the operation.
RESULTS
The incidences of PONV were 15 (33%) in midazolam group and 27 (60%) in placebo group during 24 h postoperatively. The incidence of PONV in midazolam group was significantly lower than that in placebo group (P < 0.05). There were no significant differences between groups in adverse events.
CONCLUSIONS
Midazolam 0.075 mg/kg was effective for preventing PONV after middle ear surgery without significant adverse effects.

Keyword

midazolam; middle ear surgery; postoperative nausea and vomiting (PONV)

MeSH Terms

Anesthesia
Antiemetics
Ear, Middle*
Humans
Incidence
Ketorolac
Metoclopramide
Midazolam*
Nausea*
Postoperative Nausea and Vomiting
Prospective Studies
Vomiting*
Antiemetics
Ketorolac
Metoclopramide
Midazolam