Yonsei Med J.  2012 Sep;53(5):1010-1013.

Postoperative Nausea and Vomiting after Myringoplasty under Continuous Sedation Using Midazolam with or without Remifentanil

• Jang JS
• Lee JH
• Lee JJ
• Park WJ
• Hwang SM
• Lee SK
• Lim SY

Abstract

PURPOSE
This prospective study evaluated the effects of continuous sedation using midazolam, with or without remifentanil, on postoperative nausea and vomiting (PONV) in patients undergoing myringoplasty.
MATERIALS AND METHODS
Sixty patients undergoing myringoplasty were sedated with midazolam in the presence of remifentanil (group MR), or after saline injection instead of remifentanil (group M).
RESULTS
Three patients (10%) in group M complained of nausea; two vomited. Four patients (13%) in group MR complained of nausea and vomited within 24 h after surgery. Rescue drugs were given to the six patients who vomited. No significant difference was detected between the two groups regarding the incidence or severity of nausea, incidence of vomiting, or need for rescue drugs.
CONCLUSION
Midazolam-based continuous sedation can reduce PONV after myringoplasty. Compared with midazolam alone, midazolam with remifentanil produced no difference in the incidence or severity of nausea, incidence of vomiting, or need for rescue drugs.

Keyword

Midazolam; myringoplasty; PONV; remifentanil

MeSH Terms

Humans
Incidence
Midazolam*
Myringoplasty*
Nausea
Postoperative Nausea and Vomiting*
Prospective Studies
Vomiting
Midazolam

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