Korean J Anesthesiol.  2012 Apr;62(4):343-349. 10.4097/kjae.2012.62.4.343.

The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

• Kim DS
• Koo GH
• Kang H
• Baek CW
• Jung YH
• Woo YC
• Kim JY
• Park SG

• KMID: 2238031
• DOI: http://doi.org/10.4097/kjae.2012.62.4.343

Abstract

BACKGROUND
We made a comparative study on the antiemetic effect of midazolam and ondansetron added to intravenous patient-controlled analgesia (PCA) using fentanyl with gynecologic patients undergoing pelviscopic surgery.
METHODS
The PCA using 20 microg/kg of fentanyl was started in all groups postoperatively. A dose of 16 mg of ondansetron was added to the PCA of group O (n = 30). A dose of 5 mg of midazolam was added to the PCA of group M (n = 30). While 16 mg of ondansetron and 5 mg of midazolam were added to the PCA of group MO (n = 30). Total volume of the PCA was 60 ml, and the PCA system was programmed to deliver 0.5 ml/h of continuous doses and a 0.5 ml bolus on demand, with a 15 minutes lockout interval. The incidence of postoperative nausea and vomiting (PONV), sedation score, visual analog scale (VAS) for pain, and rescue drug dose for PONV were investigated at the postanesthesia care unit (PACU), 6 hours, and 24 hours after recovery.
RESULTS
The incidence of PONV in group MO was significantly lower than in group O at PACU, 24 hours after recovery (P < 0.05). The sedation score and VAS pain score showed no differences among all groups.
CONCLUSIONS
Midazolam added to PCA using fentanyl proved more effective than ondansetron in preventing PONV without adverse effects.

Keyword

Midazolam; Ondansetron; Patient-controlled analgesia; Postoperative nausea and vomiting

MeSH Terms

Analgesia, Patient-Controlled
Antiemetics
Fentanyl
Humans
Incidence
Midazolam
Ondansetron
Passive Cutaneous Anaphylaxis
Postoperative Nausea and Vomiting
Antiemetics
Fentanyl
Midazolam
Ondansetron