Korean J Anat.  2005 Jun;38(3):243-249.

Renal Fibrosis Induced by the Partial Reduction of the Diameter of Renal Artery in Mouse

• Park KM

Abstract

Kidney artery stenosis such as atherosclerosis induces ischemic nephropathy which is caused by the reduction of blood supply to the kidneys. Since useful experimental animal models for the kidney artery stenosis is very limited, the pathophysiology of the ischemic nephropathy induced by the renal artery stenosis remain to be defined. In the present studies, I developed the mouse experimental model of kidney artery stenosis by the reduction of renal artery diameter to the out side diameter of 31-guage needle.The reduction of renal artery diameter reduces kidney size and mass. There is the severe shrink of glomeruli, tubular atrophy and infiltration of l eukocytes. In the kidney subjected to the experiment of the reduction of renal artery diameter. The expression of alpha-smooth muscle actin in the kidney partially tied the renal artery is much greater than that in the contralateral kidney. These results demonstrate that the reduction of renal artery diameter induced renal fibrosis, the reduction of renal blood flow and kidney size and that the experimental models may be useful to study the pathophysiology of ischemic nephropathy induced by renal artery stenosis as well as chronic renal failure which is involved in renal fibrotic responses.

Keyword

Renal artery stenosis; Ischemic nephropathy; Fibrosis; alpha-smooth muscle actin; Mouse

MeSH Terms

Actins
Animals
Arteries
Atherosclerosis
Atrophy
Constriction, Pathologic
Fibrosis*
Kidney
Kidney Failure, Chronic
Mice*
Models, Animal
Models, Theoretical
Renal Artery Obstruction
Renal Artery*
Renal Circulation
Actins