J Korean Soc Coloproctol.
2012 Feb;28(1):27-34. 10.3393/jksc.2012.28.1.27.
Stromal-cell-derived Factor 1-alpha Promotes Tumor Progression in Colorectal Cancer
- Affiliations
-
- 1Department of Surgery, Soonchunhyang University College of Medicine, Cheonan, Korea. ssurge@sch.ac.kr
- 2Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, Korea.
- 3Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
- KMID: 2025908
- DOI: http://doi.org/10.3393/jksc.2012.28.1.27
Abstract
- PURPOSE
Although stromal-cell-derived factor (SDF)-1alpha is suggested to be involved in tumorigenicity and tumor angiogenesis, the clinicopathological significance of its expression in colorectal cancers is not fully understood. We examined SDF-1alpha expression in colorectal cancers and investigated its relationship to clinicopathological features such as tumor staging, lymph-node metastasis, vascular invasion (VI), lymphatic invasion (LI) and neural invasion (NI).
METHODS
Specimens of 83 primary colorectal cancers were examined immunohistochemically, and the relationships between clinicopathological features and SDF-1alpha expression were analyzed. To compare the expressions between the normal colon tissue and colorectal cancer tissues, we performed Western blot analyses.
RESULTS
According to the Western blot analyses, SDF-1alpha was more highly expressed in colorectal carcinoma tissues than in normal colonic mucosa (20/21). According to the immunohistochemical stain, SDF-1alpha was associated with nodal status, distant metastasis, tumor staging, VI and LI. SDF-1alpha expression had a significant prognostic value for overall survival. Kaplan-Meier plots of survival in patients with high SDF-1alpha showed that high SDF-1alpha expression was associated with a shorter overall survival. However, no association was found between SDF-1alpha expression and other pathologic or clinical variables, including age, gender, degree of differentiation, and presence of perineural invasion.
CONCLUSION
The expression of SDF-1alpha might be associated with tumor progression in colorectal cancer. Inhibition of SDF-1alpha could be a therapeutic option in colorectal cancer patients.
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