J Korean Rheum Assoc.
2003 Sep;10(3):234-242.
Glutathione S-transferase Gene Polymorphisms and Systemic Lupus Erythematosus
- Affiliations
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- 1The Hospital for Rheumatic Diseases, Hanyang University College of Medicine, Seoul, Korea. scbae@hanyang.ac.kr
- 2Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
- 3Department of Diagnostic Laboratory Medicine, Hanyang University College of Medicine, Seoul, Korea.
- 4Department of Nutritional Sciences, University of Toronto, Toronto, Canada.
Abstract
OBJECTIVE
To determine whether GSTM1, GSTT1 and GSTP1 polymorphisms are associated with susceptibility or disease manifestations in patients with SLE.
METHODS
Two hundred eighty-six SLE patients who fulfilled the American College of Rheumatology (ACR) criteria were compared with 271 cases of age and sex matched controls to examine association between GST genotypes and susceptibility to SLE. The effect of genotype on SLE manifestations was assessed using the comparison of ACR diagnostic criteria. GST gene polymorphisms were determined by a multiplex polymerase chain reaction and antibodies to SS-A and SS-B were determined by double immunodiffusion.
RESULTS
No association was found in the comparison of GSTM1 null, GSTT1 null, GSTP1 Ile105--CONCLUSION
GSTM1 null, GSTT1 null, GSTP1 Ile105--
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