Korean J Dermatol.  2002 May;40(5):551-554.

Low-dose UVA1 Phototherapy for Localized Scleroderma

• Youn NH
• Yoo DO
• Cha SH
• Park SD

Abstract

Localized scleroderma(LS) is sclerosis of the skin characterized by one or multiple circumscribed ivory-white, indurated, sometimes confluent plaques. It has been reported that LS might result from the unbalance between synthesis and degradation of collagen in the dermis. Recently, treatment of LS with long wave UVA1, which can induce mRNA of matrix metalloproteinase-1 from dermal fibroblast and can cause apoptosis of infiltrating T lymphocytes, showed promising results. In this case, a 14-year-old girl had a 6 month history of linear, brown colored, indurated plaque on her left thigh compatible with LS histopathologically. UVA1(2.4-10.8J/cm2) was irradiated to the skin lesion at each visit, a total of 68 times for 18 months with the cumulative dose of 533J/cm2 UVA1. Her fibrotic skin lesion was resolved during treatment, but became hardened with cessation of phototherapy. She remains disease free for 11 months. We report a case of LS with improvement with low-dose UVA1 phototherapy.

Keyword

Localized scleroderma; UVA1 phototherapy

MeSH Terms

Adolescent
Apoptosis
Collagen
Dermis
Female
Fibroblasts
Humans
Matrix Metalloproteinase 1
Phototherapy*
RNA, Messenger
Scleroderma, Localized*
Sclerosis
Skin
T-Lymphocytes
Thigh
Collagen
Matrix Metalloproteinase 1
RNA, Messenger