J Korean Assoc Oral Maxillofac Surg.  2007 Oct;33(5):419-425.

The study on the effect of nanoemulsion for the prevention and treatment of gingival inflammation

• Chae CH
• Park JW

Abstract

We have found out the relationship of nanoemulsion containing nano vitamin C, E and propolis and gingival disease. We've confirmed effect of nanoemulsion through the experiment of in vivo and in vitro. We tested cell viability of gingival fibroblast cells by MTT assay and mRNA appearance of interleukin-1 beta, using mouse that was guided inflammation. Anti-microbacterial activity for Antibacterial effect's experiment was carried out by using S.aureus and E.coli. In addition, inflammation tissue has been observed with scanning electrical microscopy. In this study, expression of interleukin-1 beta was decreased after adding nanoemulsion containing nanovitamin C, E and propolis. We've also obtained good results from the test of Antibacterial effect against S.aureus and E.coli. Also, swelling of inflammation tissues observed by scanning electrical microscopy has gone down. In conclusion, we have gained confidence that nanoemulsion containing nano vitamin C, E and propolis has very high Antibacterial effect against bacteria in oral. And it made us guess that inflammation of gingival reduces after decreasing interleukin-1 beta. Thus, we expect that nanoemulsion containing nano vitamin C, E and propolis gives good effects to patient having gingival disease.

Keyword

Inflammation; Nano-vitamin C; Nano-vitamin E; Propolis; Interleukin-1 beta; Gingival fibroblast cell

MeSH Terms

Animals
Ascorbic Acid
Bacteria
Cell Survival
Fibroblasts
Gingival Diseases
Humans
Inflammation*
Interleukin-1beta
Mice
Microscopy
Propolis
RNA, Messenger
Ascorbic Acid
Interleukin-1beta
Propolis
RNA, Messenger