J Korean Assoc Oral Maxillofac Surg.  2006 Apr;32(2):107-116.

The experimental study of the bone regeneration on rabbit maxillary sinus grafting with beta-TCP

Affiliations
  • 1Division of Oral and Maxillofacial Surgery, Department of Dentstry, College of Medicine Hanyang University, Korea. hkg@hanyang.ac.kr
  • 2Department of Pathology, College of Medicine Hanyang University, Korea.

Abstract

PURPOSE
Maxillay sinus grafting is an effective treatment procedure to improve bone height in the posterior maxillar area for implant installation. Beta-tricalciumphosphate(beta-TCP) was introduced to be grafting substitute material, providing a reasonable bio-degradation time, no need for harvesting procedure. The purpose of this study is to evaluate bone healing and regeneration phase using histomorphometric and immunohistochemical analysis. MATERIAL AND METHODS:Sixteen rabbits were divided into 4 groups. Bi-lateral maxillary sinus membranes were elevated at each rabbits, beta-TCP was augmented in left sinus, autogenous bone was augmented in right sinus. The rabbits were sacrificed at 2, 4, 8 and 12 weeks. We investigated the bone regeneration and growth factor expression.
RESULTS
1. The mean new bone volume formation was 28.99+/-6.55%, 49.54+/-5.47%, 69.09+/-8.90% in autogenous grafted area, and 22.86+/-5.56%, 24.00+/-4.09%, 34.11+/-3.37% in beta-TCP area at 4, 8, 12 weeks. Therefore, new bone formation in autogenous bone was significantly higher than beta-TCP (p<0.05). 2. The BMP 2/4 expression in autogenous bone grafted area was higher at 4, 8 weeks. 3. There was no difference in expression pattern of BMP-7/PDGF/VEGF during grafted bone regeneration.
CONCLUSION
The authors we conclude that the autogenous bone graft was faster than beta-TCP in bone regeneration, and the BMP 2/4 were more important in graft bone regeneration.

Keyword

beta-TCP; Rabbit; Maxillary sinus

MeSH Terms

Bone Regeneration*
Maxillary Sinus*
Membranes
Osteogenesis
Rabbits
Regeneration
Transplants*
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