J Korean Assoc Maxillofac Plast Reconstr Surg.  2010 Jan;32(1):23-26.

EFFECTS OF HYPOXIA ON THE FORMATION OF OSTEOCLAST

Affiliations
  • 1Department of orthodontics, Seoul Municipal Boramae Hospital, Korea.
  • 2Department of Prosthodontics, Seoul Municipal Boramae Hospital, Korea.
  • 3NanoCureTech Inc, Korea.
  • 4Graduate Student of Hallym University, Korea.
  • 5Department of Prosthodontics, KangDong Sacred Heart Hospital, College of Medicine, Hallym University, Korea.
  • 6Department of Oral & Maxillogfacial Surgery, KangDong Sacred Heart Hospital, College of Medicine, Hallym University, Korea. junpark@hanafos.com

Abstract

The vascular changes in periodontal tissues cause local hypoxia which seems to affect the periodontal tissue cells. Abrupt changes in oxygen availability within the periodontium have been suggested to have a regulatory role in alveolar bone remodeling during tooth movement, bone growth or fracture healing. The purpose of this study was to study the effects of hypoxia on formation of osteoclast responsible for bone resorption, in vitro. Primary mouse bone marrow cells were cultured in normoxic (20% O2) and hypoxic (1% O2) conditions and assayed for cellular proliferation. The results obtained were as follows:

Keyword

Osteoclast; Hypoxia

MeSH Terms

Animals
Anoxia
Bone Development
Bone Marrow Cells
Bone Remodeling
Bone Resorption
Cell Proliferation
Fracture Healing
Mice
Osteoclasts
Oxygen
Periodontium
Tooth Movement
Oxygen
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