J Korean Assoc Maxillofac Plast Reconstr Surg.  2005 Sep;27(5):431-437.

The experimental study for influence of fibrin glue during healing phase after making artificial bone defect

• Rim JS
• Jang HS
• Eune JJ
• Lee ES
• Park EY
• Suh JD

Abstract

Fibrin glue is composed of fibrinogen and thrombin and used in various regions for multiple use. Basic principle is that thrombin converts fibrinogen to fibrin in the presence of Ca2+. The structure of fibrin is loose at the beginning, but after about 5 minutes a tight structure is formed under the influence of factor VIII which changes fibrin monomer into fibrin polymer. Fibrin glue is used for tissue adhesive, suture, local hemostasis, wound healing, closure of subdural space. Fibrin adhesive has been used in oral and maxillofacial surgery for hemostasis after tooth extraction in patients with coagulation disorders, skin graft fixation, reattachment of periodontal flaps, in combination with autogenous bone chips to fill the bony cavities following cyst removal, and for securing the hydroxyapatite granules for maxillary alveolar ridge augmentation. This study was designed for researching influence of fibrin glue during healing phase after making artificial bone defect.

Keyword

Fibrin glue; Rat; CSD

MeSH Terms

Alveolar Ridge Augmentation
Animals
Durapatite
Factor VIII
Fibrin Tissue Adhesive*
Fibrin*
Fibrinogen
Hemostasis
Humans
Polymers
Rats
Skin
Subdural Space
Surgery, Oral
Sutures
Thrombin
Tissue Adhesives
Tooth Extraction
Transplants
Wound Healing
Durapatite
Factor VIII
Fibrin
Fibrin Tissue Adhesive
Fibrinogen
Polymers
Thrombin
Tissue Adhesives