J Korean Assoc Maxillofac Plast Reconstr Surg.  2001 May;23(3):281-294.

THE TREATMENT OF CONGENITAL LYMPHANGIOMA WITH OK-432(PICIBANIL(R)) AND SURGICAL EXCISION

• Kim IK
• Lee SH
• Oh SS
• Choi JH
• Oh NS
• Kim WS
• Rim YI
• Yang DW

Abstract

Lymphangiomas are relatively rare benign tumors of the lymphatic system, characterized by congenital lymphatic malformation such as anastomosis or obstuction of the lymphatic channels. There are most frequently diagnosed in children younger than 3years. In contrast to that of the hemangioma, the sex distribution of the lymphangioma is nearly evenly divided. The head and neck lymphangioma represents about 70~75% of all lymphangiomas, and they are difficult to manage. Spontaneous regression is rare, and rapid intermittent enlargement occurs secondary to infection or trauma. Enlargement may cause serious sequelae such as airway obstruction, feeding difficulties, and cosmetic problems. Treatments previously used for lymphangiomas include surgical excision and intralesional injection of sclerosants. Problems associated with surgical excision include the risk of cosmetically unacceptable scarring and the risk of damage to surrounding vital structure and the high risk of incomplete excision. The sclerosants previously used have numerous other local and systemic side effects. This report describes a case that was successfully treated using OK-432 as a new sclerosant drug and secondary surgical excision for congential cavenous lymphangioma extensively enlarged to tongue, mouth floor and submandibular region.

Keyword

OK-432(picibanil(R)); Lymphangioma

MeSH Terms

Airway Obstruction
Child
Cicatrix
Head
Hemangioma
Humans
Injections, Intralesional
Lymphangioma*
Lymphatic System
Mouth Floor
Neck
Picibanil
Sclerosing Solutions
Sex Distribution
Tongue
Picibanil
Sclerosing Solutions