J Korean Soc Ther Radiol Oncol.
2006 Dec;24(4):263-271.
Effectiveness of Fentanyl Transdermal Patch (Fentanyl-TTS, Durogegic(R)) for Radiotherapy Induced Pain and Cancer Pain: Multi-center Trial
- Affiliations
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- 1University of Ulsan College of Medicine, Korea.
- 2Sungkyunkwan University College of Medicine, Korea. sjhuh@smc.samsung.co.kr
- 3Catholic University College of Medicine, Korea.
- 4Gachon University of Medicine and Science, Korea.
- 5Yonsei University College of Medicine, Korea.
- 6Inha University College of Medicine, Korea.
- 7Ajou University School of Medicine, Korea.
- 8Keimyung University of Dongsan Medical Center, Korea.
- 9Korea University College of Medicine, Korea.
- 10Chungbuk National University College of Medicine, Korea.
- 11Dankook University College of Medicine, Korea.
- 12Inje University College of Medicine, Korea.
- 13Wonju Christian Hospital, Korea.
- 14Eulji University College of Medicine, Korea.
- 15Gyeongsang National University School of Medicine, Korea.
- 16Seoul National University College of Medicine, Korea.
- 17Pochon Cha University College of Medicine, Korea.
- 18Daejeon St. Mary's Hospital, Korea.
- 19Soonchunhyang University College of Medicine, Korea.
- 20Chonnam National University Medical School, Korea.
- 21National Medical Center, Korea.
- 22Yeungnam University College of Medicine, Korea.
- 23Halla General Hospital, Korea.
- 24Catholic University of Daegu Division of Medicine, Korea.
- 25Chungang University College of Medicine, Korea.
- 26Samsung Biomedical Research Institute, Korea.
Abstract
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PURPOSE: To evaluate the effectiveness and safety of fentanyl-TTS in the management of radiotherapy induced acute pain and cancer pain treated with radiotherapy.
MATERIALS AND METHODS
Our study was open labelled prospective phase IV multi-center study. the study population included patients with more 4 numeric rating scale(NRS) score pain although managed with other analgesics or more than 6 NRS score pain without analgesics. Patients divided into two groups; patients with radiotherapy induced pain (Group A) and patients with cancer pain treated with radiotherapy (Group B). All patients received 25 ug/hr of fentanyl transdermal patch. Primary end point was pain relief; second end points were change in patient quality of life, a degree of satisfaction for patients and clinician, side effects.
RESULTS
Between March 2005 and June 2005, 312 patients from 26 participating institutes were registered, but 249 patients completed this study. Total number of patients in each group was 185 in Group A, 64 in Group B. Mean age was 60 years and male to female ratio was 76:24. Severe pain NRS score at 2 weeks after the application of fentanyl was decreased from 7.03 to 4.01, p=0.003. There was a significant improvement in insomnia, social functioning, and quality of life. A degree of satisfaction for patients and clinician was very high. The most common reasons of patients' satisfactions was good pain control. Ninety six patients reported side effect. Nausea was the most common side effect. There was no serious side effect.
CONCLUSION
Fentanyl-TTS was effective in both relieving pain with good tolerability and improving the quality of life for patients with radiotherapy induced acute pain and cancer pain treated with radiotherapy. The satisfaction of the patients and doctors was good. There was no major side effect.
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