J Korean Acad Periodontol.  2000 Sep;30(3):609-618. 10.5051/jkape.2000.30.3.609.

Morphological features of Cyclosprin A-induced Gingival Hyperplasia

Affiliations
  • 1Department of Periodontology, College of Dentistry, Yonsei University Research Institute for Periodontal Regeneration, Korea.
  • 2Department of Periodontology, National Health Insurance Corporation Ilsan Hospital, Korea.
  • 3Department of Oral Pathology, College of Dentistry, Yonsei University, Korea.

Abstract

Cyclosporin A(CsA) is now widely used to treat organ transplant recipients. But CsA has various short-and long-term side effects. Especially, gingival hyperplasia is not easy to resolve since its nature is still unknown. This study discusses the pathogenesis of CsA-induced gingival hyperplasia on the basis of data obtained from light and electron microscopic studies of biopsis from patients on CsA treatment after kidney transplantation. Light microscopically, the multilayered squamous epithelium showed an irregular surface of parakeratosis and deep invaginations in the subepithelial tissue. At lamina propria, we observed bundles of irregularly arranged collagen fiber, some fibroblasts, numerous capillary vessels and a large diffuse infiltration of plasma cells. Ultrastructurally, many fibroblasts, collagen fibers, collagen fibrils were present in lamina propria. On the basis of the data collected, we propose that the morphological features of the dimensional increase in gingival tissue associated with CsA treatment in kidney transplant patients may be considered proliferative fibroblasts, collagen fibers, collagen fibrils in lamina propria.

Keyword

Cyclosporin A; gingival hyperplasia; lamina propria; collagen fibers; fibroblasts; collagen fibrils

MeSH Terms

Capillaries
Collagen
Cyclosporine
Epithelium
Fibroblasts
Gingival Hyperplasia*
Humans
Kidney
Kidney Transplantation
Mucous Membrane
Parakeratosis
Plasma Cells
Transplants
Collagen
Cyclosporine
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