J Korean Acad Periodontol.  2007 Dec;37(4):871-879. 10.5051/jkape.2007.37.4.871.

The effects of novel biodegradable amorphous Calcium Phosphate on bone regeneration in rat calvarial defects

• Choi JY
• Chae GJ
• Kim CS
• Lee YK
• Cho KS
• Chai JK
• Kim CK
• Choi SH

• KMID: 1999625
• DOI: http://doi.org/10.5051/jkape.2007.37.4.871

Abstract

PURPOSE
The purpose of this study was to evaluate the bone regeneration of novel biodegradable amorphous calcium phosphate. MATERIALS AND METHOD: An 8-mm, calvarial, critical-size osteotomy defect was created in each of 20 male Sprague-Dawley rats(weight 250~300g). The animals were divided into two groups of 10 animals each and allowed to heal for 2 weeks(10 rats) or 8 weeks(10 rats). The first group was the control group and the other group was the experimental group which received the novel biodegradable calcium phosphate.
RESULTS
The healing of the calvarium in the control group was uneventful. The histologic results showed little bone formation in the control group. The experimental group which received the novel biodegradable calcium phosphate showed a normal wound healing. There were a lot of new bone formation around the biomaterial in 2 weeks. The bone formation increased in 8 weeks when compared to 2 weeks and there was a significant bone increase as well(P<0.01).The novel biodegradable calcium phosphate showed statistical significance when compared to the control group (P<0.05). The novel biodegradable calcium phosphate in 8 weeks showed a significant increase in bone formation when compared to 2 weeks (40.4+/-1.6)(%). The biodegradable calcium phosphate which is made from mixing calcium phosphate glass(CPG), NaCO and NaOH solution, is biocompatible, osteoconductive and has a high potency of bone formation.
CONCLUSION
We can conclude that the novel biodegradable calcium phosphate can be used as an efficient bone graft material for its biodegradability and osteoconductivity.

Keyword

novel biodegradable calcium phosphate; bone; bone regeneration

MeSH Terms

Animals
Bone Regeneration*
Calcium*
Humans
Male
Osteogenesis
Osteotomy
Rats*
Rats, Sprague-Dawley
Skull
Transplants
Wound Healing
Calcium