J Korean Soc Endocrinol.  2002 Feb;17(1):43-47.

Korean Adult Growth Hormone Deficiency Treatment Registry

• Kim SW
• Kim SY
• Nam SY
• Chung YS
• Chung JH
• Jung IK
• Hahm JR
• Shong M
• Kim DS
• Lee SK
• Moon SD
• Yoon HK
• Kim DM
• Kim SW
• Park HK

Abstract

BACKGROUND: Adult growth hormone (GH) deficiency is related with decreased lean body mass, increased body fat, and poor quality of life. In western countries, adult GH deficiency treatment registriesy provide a database of the effects and safety of GH deficiency treatment. The Korean Adult Growth Hormone Study Group of the Korean Society of Endocrinology register adult GH deficiency since 1996. METHEODS: Subjects were aged over 15 years, had organic hypothalamo-pituitary disease, and GH deficiency as documented by GH stimulation test or serum insulin-like growth factor-I (IGF-I) level. The underlying etiology for GH deficiency, serum IGF-I level, starting and maintenance dose, and adult GH deficiency assessment (AGHDA) score were investigated.
RESULTS
From January 1996 to May 2001. 115 patients were enrolled. Mean age was 43.7 13.8 years and 60% were female. Thirteen medical institutions were involved in the registry. The most common underlying diseases were Sheehan's syndrome and pituitary adenomas. GH starting dose was from 0.4 to 1.0 units. Maintenance dose was between 0.5 and 1.2 units. Serum IGF-I levels were increased after GH treatment (0-week, 93.7 69.7 ng/mL; 2-weeks, 184.9 89.0 ng/mL; 6-weeks, 188.4 94.8 ng/mL; 10-weeks, 207.6 111.1 ng/mL; 6 months, 281.9 95.5 ng/mL). AGHDA scores slightly improved from 10.25 6.70 to 8.58 5.47 after 6 months of GH deficiency treatment.
CONCLUSION
The GH Treatment Registry will be beneficial in monitoring the effects of GH deficiency treatment on Korean adult GH deficient subjects

MeSH Terms

Adipose Tissue
Adult*
Endocrinology
Female
Growth Hormone*
Humans
Hypopituitarism
Insulin-Like Growth Factor I
Pituitary Neoplasms
Quality of Life
Growth Hormone
Insulin-Like Growth Factor I