Korean J Nephrol.  1998 Nov;17(6):973-977.

A Case of Furosemide Induced Acute Interstitial Nephritis

• Im KH
• Kim YO
• Hong SH
• Park JM
• Yoon SA
• Kim YS
• Jung ES
• Chun KA
• Bang BK

Abstract

Drug-induced acute interstitial nephritis is characterized by renal interstitial inflammatory cell infiltration and commonly presents as acute renal failure. This is caused mainly by methicillin, non-steroidal antiinflammatory drugs, sulfonamide diuretics such as thiazide, but cases induced by furosemide are rare. We report a patient with acute interstitial nephritis causing reversible acute renal failure and dermatitis while she was taking furosemide. A 37-year old woman was referred to our hospital because of generalized skin rash and non-oliguric acute renal failure. She had peripheral eosinophilia (1,577/mm3) and serum creatinine level of 6.8mg/dL. Skin biopsy showed leukoclastic vasculitis and percutaneous renal biopsy showed severe interstitial infiltration of lymph ocyte and mild interstitial fibrosis with focal tubular atrophy. After withdrawal of furosemide, renal function and skin lesions were completely recovered.

Keyword

Acute interstitial nephritis; Acute renal failure; Furosemide; Skin rash

MeSH Terms

Acute Kidney Injury
Adult
Atrophy
Biopsy
Creatinine
Dermatitis
Diuretics
Eosinophilia
Exanthema
Female
Fibrosis
Furosemide*
Humans
Methicillin
Nephritis, Interstitial*
Skin
Vasculitis
Creatinine
Diuretics
Furosemide
Methicillin