J Korean Soc Emerg Med.
2016 Aug;27(4):371-375. 10.0000/jksem.2016.27.4.371.
A Case of Methomyl-induced Acute Allergic Tubulointerstitial Nephritis
- Affiliations
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- 1Department of Internal Medicine, Chosun University Hospital, Chosun University Medical School, Gwangju, Korea.
- 2Department of Emergency Medicine, Chosun University Hospital, Chosun University Medical School, Gwangju, Korea. eryongjin@chosun.ac.kr
- KMID: 2350891
- DOI: http://doi.org/10.0000/jksem.2016.27.4.371
Abstract
- Drug-induced interstitial nephritis is one of the causes of acute kidney injury. Although methomyl is widely used as an insecticide in many countries, methomyl-induced interstitial nephritis has not been reported thus far in the general population. We report a case of a 39-year-old male patient with acute allergic tubulointerstitial nephritis due to methomyl intoxication. He took methomyl 250 mL to commit suicide. He was treated with hemodialysis, but his renal function continued to deteriorate. Kidney biopsy demonstrated mononuclear cell and some eosinophils infiltration into the renal interstitium with tubular invasion. Immediate steroid pulse therapy, appropriate education, and conservative management resulted in gradual restoration of his renal function. This case suggests that methomyl may be a causative allergen inducing acute interstitial nephritis in some patients.
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