Korean J Med.  2014 Aug;87(2):219-223. 10.3904/kjm.2014.87.2.219.

Dioscorea Quinqueloba-Induced Tubulointerstitial Nephritis

• Jeon JM
• Park YK
• Jeon MY

• KMID: 1710035
• DOI: http://doi.org/10.3904/kjm.2014.87.2.219

Abstract

Drug-induced tubulointerstitial nephritis is one cause of acute kidney injury. Although traditional remedies have been widely used in South Korea, Dioscorea quinqueloba-induced tubulointerstitial nephritis has not been reported in the general population. A 72-year-old male patient was transferred to our hospital with pulmonary edema, oliguria, decreased mentality, severe generalized edema after taking D. quinqueloba 25 days ago. His initial lab findings showed a blood urea nitrogen level of 43.4 mg/dL, a creatinine level of 5.3 mg/dL. Urinalysis revealed SG (1.015), blood (many), protein (++) and WBC (0-3/HPF). Kidney biopsy demonstrated severe mononuclear cell infiltration into the renal interstitium with mild tubular atrophy. Aggressive renal replacement therapy and supportive care resulted in gradual restoration of his renal function. This case implies that D. quinqueloba may be one cause that induces tubulointerstitial nephritis in some patients.

Keyword

Dioscorea quinqueloba; Tubulointerstitial nephritis; Acute kidney injury

MeSH Terms

Acute Kidney Injury
Aged
Atrophy
Biopsy
Blood Urea Nitrogen
Creatinine
Dioscorea*
Edema
Humans
Kidney
Korea
Male
Nephritis, Interstitial*
Oliguria
Pulmonary Edema
Renal Replacement Therapy
Urinalysis
Creatinine