Korean J Thorac Cardiovasc Surg.  2000 Jul;33(7):541-546.

A Experimental Study for the Effect of Sodium Carboxymethyl Cellulose on Prevention of Percardial Adhesion

• Lee SY
• Jeon CW
• Lee MB
• Lee KR
• Koh ES
• Uhm YI

Abstract

BACKGROUND
Pericardial adhesion poses a major problem during re-operative cardiac surgery. The purpose of this study was to determine the effect of sodium carboxymethol cellulose on experimental pericardial adhesions. MATERIAL AND METHOD: Twenty-four rabbits were divided into 2 groups of 12 rabbits each and pericardial mesothelial injury was induced by abrasion. Group A included rabbits receiving intrapericardial injection of Ringer's solution, and Group B included rabbits receiving intrapericardial injection of 3% sodium carboxymethoyl cellulose solution. Three weeks after the surgery, the incidence of adhesions in Group A was compared with that in Group B. RESULT: Pericardial adhesions were evaluated by tenacity and type scores. Tenacity scores of 3 or greater were considered clinically significant adhesion. Pericardial adhesion was found in 100% of rabbits in group A. However 25% of the rabbits in Group B had pericardial adhesions(p<0.0001). Type scores were also considered clinically significant between 2 groups.
CONCLUSION
Our findings demonstrated that intrapericardial injection of 3% sodium carboxymethyl cellulose solution reduced the incidence of pericardial adhesions in an animal models.

Keyword

Pericardium; Adhesion; Models, experiment

MeSH Terms

Carboxymethylcellulose Sodium*
Cellulose
Incidence
Models, Animal
Pericardium
Rabbits
Sodium*
Thoracic Surgery
Carboxymethylcellulose Sodium
Cellulose
Sodium