J Korean Foot Ankle Soc.  2009 Jun;13(1):7-13.

The Effect of Hyaluronate-Carboxymethyl Cellulose on Tissue Adhesion after Achilles Tendon Tenorraphy in Rats

• Lee JH
• Jeong BO
• Kim GY

Abstract

PURPOSE: The purpose of this study was to evaluate the effect of Sodium hyaluronate-Sodium carboxymethyl cellulose (HA-CMC) on tissue adhesion after tenorrhapy in tenotomized Achilles tendon of the Sprague-Dawley rat.
MATERIALS AND METHODS
Twenty-eight legs of 14 Sprague-Dawley rat were used in study. After tenotomy of the Achilles tendons, tenorrhaphies were performed. Simple tenorrhaphy without any other procedures were performed on the left Achilles tendons (control group), and additional HA-CMC injections were done prior to the tenorrhaphy on the right Achilles tendons (HA-CMC group). Gross and histological examinations were made to identify differences between the two groups, 1, 2, 6, 8, 10, 12 and 14 weeks respectively.
RESULTS
Distinct decrease in granulation tissues and adhesions were seen in the HA-CMC group during gross inspection at 6 and 8 week after the operation. On histological analysis of the HA-CMC group, although increased infiltrations of inflammation cells were observed during 1 week, less adhesion were seen at 6, 8 and 10 weeks after the operation. In HA-CMC group, superior healing processes were seen at 6, 8 and 10 weeks and less fibrotic changes, compared to control group, were seen at 2 and 6 weeks.
CONCLUSION
Prevention of adjacent tissue adhesion was made possible through decrease in collagen deposition and fibrosis by injecting HA-CMC before tenorrhaphy of Achilles tendon. Also, histologically faster healing process of the collagen fibers within the Achilles tendon was observed

Keyword

Achilles tendon; Adhesion; Sodium hyaluronate-Sodium carboxymethyl cellulose

MeSH Terms

Achilles Tendon
Animals
Carboxymethylcellulose Sodium
Cellulose
Collagen
Fibrosis
Granulation Tissue
Inflammation
Leg
Rats
Sodium
Tenotomy
Tissue Adhesions
Carboxymethylcellulose Sodium
Cellulose
Collagen
Sodium