Korean J Thorac Cardiovasc Surg.  2010 Dec;43(6):596-601.

A Study of the Effect of a Mixture of Hyaluronic Acid and Sodium Carboxymethyl Cellulose (Guardix-sol(R)) on the Prevention of Pericardial Adhesion

• Lee SA
• Kim JS
• Kim JS
• Hwang JJ
• Lee WS
• Kim YH
• Choi YK
• Chee HK

Abstract

BACKGROUND
This study was designed to evaluate the efficacy of a mixture of hyaluronic acid and sodium carboxymethyl cellulose (Guardix-sol(R)) on experimental pericardial adhesion. MATERIAL AND METHOD: Thirty rats were divided into 2 groups of 15 rats each and pericardial mesothelial injury was induced during surgery by abrasion. In the control group, blood and normal saline were administered into pericardium; in the test group, blood and HA-CMC solution were administered. Pericardial adhesions were evaluated at 2 weeks (n=5), 4 weeks (n=5), and 6 weeks (n=5) after surgery. The severity of adhesions was graded by macroscopic examination, and the adhesion tissue thickness was analyzed microscopically with Masson trichrome stain and an image processing program. RESULT: The test group had significantly lower macroscopic adhesion scores (2.9+/-0.6 : 3.9+/-0.4, p<0.000) compared with the control group. For microscopic adhesion tissue thickness, the test group had lower scores compared with the control group, but this difference was not statistically significant (91.73+/-49.91 : 117.67+/-46.4, p=0.106).
CONCLUSION
We conclude that an HA-CMC solution (Guardix-sol(R)) reduces the formation of pericardial adhesions in this animal model.

Keyword

Pericardium; Adhesion; Animal model

MeSH Terms

Animals
Azo Compounds
Carboxymethylcellulose Sodium
Eosine Yellowish-(YS)
Hyaluronic Acid
Methyl Green
Models, Animal
Pericardium
Rats
Sodium
Azo Compounds
Carboxymethylcellulose Sodium
Eosine Yellowish-(YS)
Hyaluronic Acid
Methyl Green
Sodium