Korean J Psychopharmacol.  1998 Oct;9(2):137-142.

Effect of Atypical Antipsychotics, Risperidone on Serum Creatine Phosphokinase

• Kim EJ
• Yun KW
• Woo HW

Abstract

OBJECTIVES
This prospective study was designed to investigate the effect of serotonergic atypical antipsychotics on serum creatine phosphokinase. METHOD: The subjects were 60 inpatients who were medicated risperidone and nemonapride, atypical antipsychotics. The symptoms of NMS such as fever and muscle rigidity and the level of CRK of all subjects were assessed on the 5th, 10th, 20th, and 30th medication day.
RESULTS
Sociodemographic variables, such as sex and mean age and number of intramuscular injection were not different between the risperidone and the nemonapride group. Maximum dosage of antipsychotics (chlorpromazine equivalent) was significantly higher in the nemonapride group. Fever and muscle rigidity were not different between two groups (p>0.05). The change of serum creatine phosphokinase was significantly higher in the risperidone group than the nemonapride group (p<0.05).
CONCLUSIONS
Serum CRK showed a significant increase in risperidone than nemonapride group. Such a finding is primarily caused by the effect of atypical antipsychotics mediating serotonergic effects. It is not recommanded to stop the medication by misunderstanding the effect as a prodrome symptom of NMS.

Keyword

Risperidone; Serum creatine phosphokinase

MeSH Terms

Antipsychotic Agents*
Creatine Kinase*
Creatine*
Fever
Humans
Injections, Intramuscular
Inpatients
Muscle Rigidity
Negotiating
Prospective Studies
Risperidone*
Antipsychotic Agents
Creatine
Creatine Kinase
Risperidone