Korean J Med.
2001 Oct;61(4):439-443.
Cyclophosphamide: Induced lung toxicity in a patient with Wegener's granulomatosis
- Affiliations
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- 1Department of Nephrology, School of Medicine, Ajou University, Suwon, Korea.
- 2Department of Pulmonology & Critical Care Medicine, School of Medicine, Ajou University, Suwon, Korea.
- 3Department of Diagnostic Radiology, School of Medicine, Ajou University, Suwon, Korea.
- 4Department of Pathology, School of Medicine, Ajou University, Suwon, Korea.
Abstract
- Lung toxicity associated with cyclophosphamide use is a rare but serious side effect, that may result in a fatal course. However no such cases have been reported in Korea, so clinicians would not be alert to this adverse effect. We recently experienced a woman with Wegener's granulomatosis and idiopathic pulmonary fibrosis. This patient had been administered 12 grams of cyclophosphamide for 4 months. At that time of admission, She felt aggravating dyspnea on exertion for 2 weeks. Her chest x-ray and high resolution CT revealed aggravated reticular opacities and ground glass appearances. Dyspnea was improved and ground glass appearances on HRCT was disappeared after discontinuation of cyclophosphamide. We diagnosed this case as cyclophosphamide-induced pneumonitis and report it with a brief review of the literature.
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