Korean J Gynecol Oncol Colposc.  2002 Sep;13(3):228-236.

Expression of Angiopoietin-1 & -2 mRNA in Invasive Cervical Cancer

• Yoo MY
• Moon HS
• Park HM
• Chung HW
• Kim SC

Abstract

OBJECTIVE
The angiopoietins (Ang) are recently described as one of growth factors for vascular endothelium. This study was aimed to investigate the Ang-1 and Ang-2 mRNA expression between in cervical cancer and in normal cervix and to assess the relationships among their expression and other prognostic factors of cervical cancer.
PATIENTS AND METHODS
Ang-1 and Ang-2 mRNA expression were investigated by quantative competitive PCR between in cervical cancer of 34 cases and in normal cervix of 14 cases at Ewha Womans University Mokdong Hospital from March 1998 to June 2000.
RESULTS
Both in cervical cancer and normal cervical tissue, 612 bp sized Ang-1 mRNA and 518 bp sized Ang-2 mRNA were expressed. In comparison to normal cervix, their expression was significantly elevated in cervical cancer (p<0.05). A definite correlation was found between Ang-1 mRNA expression and clinical stage of cervical cancer (p<0.05). There was significant correlation among Ang-2 mRNA expression and clinical stage, tumor sizes, SCC-Ag levels, lymph node metastasis of cervical cancer (p<0.05).
CONCLUSION
The expression of Ang-1 & -2 mRNA could be associated with the progression and metastasis of cervical cancer and might have a role as a prognostic parameter in cervical cancer.

Keyword

Cervical cancer; Angiopoietin

MeSH Terms

Angiopoietin-1*
Angiopoietins
Cervix Uteri
Endothelium, Vascular
Female
Humans
Intercellular Signaling Peptides and Proteins
Lymph Nodes
Neoplasm Metastasis
Polymerase Chain Reaction
RNA, Messenger*
Uterine Cervical Neoplasms*
Angiopoietin-1
Angiopoietins
Intercellular Signaling Peptides and Proteins
RNA, Messenger