Korean J Obstet Gynecol.  2004 Jun;47(6):1171-1178.

Expression of Angiopoietin-1 and Angiopoietin-2 mRNA in Eutopic and Ectopic Endometrium

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.
  • 2Department of Obstetrics and Gynecology, College of Medicine, Ewha Woman's University, Seoul, Korea.

Abstract


OBJECTIVE
To investigate the mRNA expression of Angiopoietin (Ang)-1 and Ang-2 in ectopic and eutopic endometrium from women with or without endometriosis throughout the menstrual cycle.
METHODS
Total RNA was extracted and reverse transcribed into cDNA. The expression of Ang-1 and Ang-2 was examined by quantative competitive PCR (QC PCR) and each result was analyzed by Kruskal- Wallis analysis and Mann-Whitney U-test.
RESULTS
The expression of Ang-1 mRNA was statistically significantly higher in endometrium of follicular phase from women with endometriosis compared to that from normal ones in the follicular phase. Endometriotic tissues expressed significantly lower Ang-2 mRNA compared to endometrium from women without endometriosis.
CONCLUSION
We suggested that the expression of Ang-1 mRNA could be associated with the pathogenesis of endometriosis and might have a role as neovascularizaton and survival of ectopic endometrium.

Keyword

Endometriosis; Angiopoietin-1; Angiopoietin-2
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