Asian Spine J.
2008 Dec;2(2):109-113. 10.4184/asj.2008.2.2.109.
The Effectiveness of Gefitinib on Spinal Metastases of Lung Cancer: Report of Two Cases
- Affiliations
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- 1Department of Orthopedic Surgery, University of Toyama, Faculty of Medicine, Toyama, Japan. zukawa@med.u-toyama.ac.jp
- 2Department of Orthopedic Surgery and Center for Respiratory diseases, Toyama Rosai Hospital, Toyama, Japan.
- KMID: 1972537
- DOI: http://doi.org/10.4184/asj.2008.2.2.109
Abstract
- Lung cancer has a high mortality rate and is often diagnosed at the metastatic stage. Recently, gefitinib, a molecule target therapeutic drug, has offered a new approach for patients with non-small-cell lung cancer (NSCLC). This report describes the effects of gefitinib on bone metastases in two patients with NSCLC. The pain induced by a bone metastasis was relieved after the administration of gefitinib. Furthermore, the radiographs and CT findings showed sclerotic changes that matched those of the metastatic bone tumor after gefitinib administration in both patients. It is believed that gefitinib inhibited tumor cell proliferation and induced normal bone formation. In patients with NSCLC, gefitinib may be effective in the treatment of bone metastases.
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