Korean J Radiol.  2014 Apr;15(2):300-304. 10.3348/kjr.2014.15.2.300.

Progressive Multiple Cystic Changes in Both Lungs in a Patient Treated with Gefitinib for Lung Adenocarcinoma with Multiple Lung Metastases

• Ryu YJ
• Chun EM
• Lee SN
• Shim SS

• KMID: 1705587
• DOI: http://doi.org/10.3348/kjr.2014.15.2.300

Abstract

Gefitinib is regarded as a relatively safe agent for the treatment of an advanced non-small cell lung cancer (NSCLC). Pulmonary toxicity such as interstitial lung disease associated with gefitinib is uncommon with an estimated all time incidence around 1% worldwide. Moreover, a case of gefitinib associated with pulmonary cystic changes has not been reported yet. In this report we present a case of progressive multiple air cystic changes in both lungs in a patient with NSCLC and intrapulmonary metastases who underwent a gefitinib therapy.

Keyword

Gefitinib; Non-small cell lung cancer; Cystic change

MeSH Terms

Antineoplastic Agents/*adverse effects
Brain Neoplasms/secondary
Carcinoma, Non-Small-Cell Lung/*drug therapy/secondary
Cysts/*chemically induced
Female
Humans
Lung/pathology
Lung Diseases/*chemically induced
Lung Diseases, Interstitial
Lung Neoplasms/*drug therapy
Middle Aged
Quinazolines/*adverse effects
Antineoplastic Agents
Quinazolines