Ewha Med J.  1996 Jun;19(2):269-275. 10.12771/emj.1996.19.2.269.

Altered Expressions of PLC-gamma1 in Various Types of Human Cancer

Affiliations
  • 1Department of Pathology and Division of Cell and Tissue Biology, Medical College and Ewha Medical Research Center, Ewha Womans University, Korea.

Abstract

BACKGROUND
Phospholipase C isozymes(PLCs) paly a central role in ligand-mediated signal transduction for cellular activity such as proliferation and differentiation. However, the biolog-ical significance of their molecules in carcinogenesis or tumor progression is not determined precisely yet.
MATERIALS AND METHODS
Usnig PLC-gamma1 specific antibody, we have examined the relative contents of PLC-gamma1 in various types of human cancer tissue, by immunoblotting and imm-unohistochemistry techniques. Several oncogene studies and DNA ploidy sutdy were per-formed additionally insome tumors.
RESULTS
Most malignancy showed elevated contentesof PLC-gamma1, especially in colorectal and breast cancer, whereas hepatocellular carcinoma revealed decreased expression pf PLC-gamma1. onco-protein expression was correlated with PLC-gamma1 expression in some tumors. In hepatocellular carcinoma, DNA ploidy has an influenc to PLC-gamma1 expression in most of the cases.
CONCLUSION
In conclusion, alteration or imbalance of the PLC-gamma1 mediated signal trans-duction may have a significant role in the devlelopment or progression of cancer. These findings not only have important implications for increasing our understanding of multistage car-cinogenesis but they also have an impact on strategies for diagnosis and theraly of cancers.

Keyword

Phospholipase C-gamma1; Cancer; Signal transduction
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