Ewha Med J.  2004 Sep;27(2):87-91. 10.12771/emj.2004.27.2.87.

Analysis of EBV in Extranodal NK/T Cell Lymphoma

• Cho MS
• Woo SY

• KMID: 1964090
• DOI: http://doi.org/10.12771/emj.2004.27.2.87

Abstract

OBJECTIVES
Epstein-Barr virus(EBV) is associated with development of various types of lymphoma, especially NK/T cell lymphoma. Recently, its subtypes and LMP-1, major oncoprotein of EBV, have been studied. We investigated the frequency of EBV, its subtypes, and LMP-1 status on the cases diagnosed at Ewha university hospital between 1993 and 2002. MATERIAL AND METHODS: Sixteen cases of NK/T cell lymphomas were studied. In situ hybridization for EBER-1 mRNA and PCR for EBV subtypes and 30 base pair deletion of LMP-1 were done.
RESULTS
All cases showed EBV positivity by EBER in situ hybridization. All cases contained Type A viruses and 10 cases(62.5%) revealed LMP-1 30bp deletion.
CONCLUSION
EBV act as a causative role in the development of NK/T cell lymphoma. The exact role of LMP-1 30bp deletion variant in the lymphomatogenesis should be studied with larger number of cases.

Keyword

Epstein-Barr virus; Genotype; LMP-1; NK/T cell Lymphoma; Extranodal

MeSH Terms

Base Pairing
Genotype
Herpesvirus 4, Human*
In Situ Hybridization
Lymphoma*
Polymerase Chain Reaction
RNA, Messenger
RNA, Messenger