Ann Dermatol.  1998 Jul;10(3):190-194. 10.5021/ad.1998.10.3.190.

A Case of NCAM-positive Nasal Type T/NK-Cell Lymphoma

• Kim JW
• Nam SH
• Kim KJ
• Kim CM
• Lee CJ

• KMID: 2359789
• DOI: http://doi.org/10.5021/ad.1998.10.3.190

Abstract

We herein report a case of nasal type T/natural killer(NK)-cell lymphoma(TNKCL). This lymphoma is characterized by the expression of CD2, CD43 and NCAM(CD56) antigen, an aggressive clinical course, frequent extranodal spreading, a strong association with Epstein-Barr virus(EBV), and the absence of T-cell receptor(TCR) gene rearrangement. NCAM antigen is known to be a possible determinant of extranodal dissemination of peripheral T-cell lymphoma(PTCL). The patient is a 70-year-old male with skin lesion on his forearm. Histopathological and immunohistochemical studies were diagnostic of EBV-associated TNKCL. Untill now, he has failed to respond to anticancer therapy.

Keyword

Nasal type T/NK-cell lymphoma; NCAM; EBV

MeSH Terms

Aged
Forearm
Gene Rearrangement
Herpesvirus 4, Human
Humans
Lymphoma*
Male
Neural Cell Adhesion Molecules
Skin
T-Lymphocytes
Neural Cell Adhesion Molecules