J Korean Pediatr Soc.  1999 Mar;42(3):403-411.

The Relationship between Total Serum IgE, Allergen-Specific IgE, and Skin Prick Test in Children with Atopic Asthma

Affiliations
  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Abstract

PURPOSE: Skin prick test and determination of allergen-specific IgE antibodies in serum are methods commonly used to diagnose allergies. Several studies indicate that skin test and specific IgE have roughly the same diagnostic precision, although discrepancies exist. The objective of this study was to evaluate the influence of total serum IgE on the relation between skin prick test and allergen-specific IgE antibody.
METHODS
We performed skin prick tests using 14 major inhalant allergens and measured total IgE and specific IgE for two major allergens [Dermatophagoides farinae(D.f.) and Dermatophagoides pteronyssinus (D.p.)] in serum of 230 children with atopic asthma.
RESULTS
Positivity of skin prick test was 92.2% for D.f., 89.6% for D.p., and 22.6% for cockroach. Allergen/Histamine(A/H) ratio and allergen-specific IgE score showed a positive correlation for D.f.(r=0.39, P<0.01), and for D.p.(r=0.38, P<0.01). Total serum IgE and allergen-specific antibody score showed a positive correlation for D.f.(r=0.50, P<0.01), and for D.p.(r=0.53, P<0.01). There was no correlation between total serum IgE and A/H ratio on skin prick test for the two allergens. However, total serum IgE had the tendency to increase according to the number of positive allergens on skin prick test. At each level of A/H ratio for D.f. and D.p. on skin prick test, patients with high total IgE had higher antigen-specific IgE scores than patients with low total IgE.
CONCLUSION
Our results show that the relationship between skin prick test and antigen-specific IgE was influenced by the level of serum total IgE. This indicates that the level of serum total IgE should be taken into account when skin prick test and allergen-specific IgE are compared.

Keyword

Atopic Asthma; Total Serum IgE; Allergen-Specific IgE; Skin Prick Test; Dermatophagoides farinae; Dermatophagoides pteronyssinus

MeSH Terms

Allergens
Antibodies
Asthma*
Child*
Cockroaches
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Humans
Hypersensitivity
Immunoglobulin E*
Skin Tests
Skin*
Allergens
Antibodies
Immunoglobulin E
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