Korean Circ J.
2001 Nov;31(11):1215-1224. 10.4070/kcj.2001.31.11.1215.
Effects of Antioxidant Supplementation on the Lipid Peroxidation and Antioxidative Enzyme Activities in Patients with Coronary Heart Disease
- Affiliations
-
- 1Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. jejun@knu.ac.kr
- 2Department of Culinary Science, Honam University, Kwangju National University, Daegu, Korea.
- 3Department of Preventive Medicine and Public Health, School of Medicine, Kyungpook National University, Daegu, Korea.
- 4Department of Food and Nutrition, Daegu University, Kyungpook National University, Daegu, Korea.
- 5Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu, Korea.
- 6Department of Food and Nutrition, Daegu Hyosung Catholic University, Kyungpook, Korea.
- KMID: 1938942
- DOI: http://doi.org/10.4070/kcj.2001.31.11.1215
Abstract
- BACKGROUND AND OBJECTIVES
The purpose of this study was to evaluate whether antioxidant supplementation with tocopherol, vitamin C, beta-carotene, and selenium reduces lipid peroxide levels and increases antioxidative enzyme activities in patients with coronary heart disease.
SUBJECTS AND METHODS
Eighty nine patients participated in a randomized, double-blind, placebo-controlled trial. The antioxidant group (45 patients) was given daily doses of tocopherol (400 IU), vitamin C (500 mg), beta-carotene (15 mg), and selenium (50 microgram) and the placebo group (44) received placebo. Thirty eight of the antioxidant group (84.4%) and thirty nine (88.6%) of the placebo group completed the 3-month supplementation.
RESULTS
Serum levels of alpha-tocopherol, vitamin C and beta-carotene were significantly increased in the antioxidant group as compared to the placebo group (p<0.05), however, retinol was not. Thiobarbituric acid-reactive substances (TBARS) decreased significantly (0.6 nmol MDA/mL) in the antioxidant group as compared with the level (0.09 nmol MDA/mL) seen in the placebo group (p<0.05). Antioxidants did not affect the oxidized-LDL level. The activities of erythrocyte superoxide dismutase (SOD) significantly increased by 0.85 unit/mg hemoglobin in the antioxidant group versus 0.27 unit/mg hemoglobin in the placebo group (p<0.01), and the activities of erythrocyte catalase significantly decreased by 0.04 unit/mg hemoglobin versus 3.37 unit/mg hemoglobin (p<0.01). However, the activities of erythrocyte glutathione peroxidase (GPX) increased insignificantly by 0.09 unit/mg hemoglobin vs 0.1 unit/mg hemoglobin.
CONCLUSION
These results suggest that antioxidant supplementation with tocopherol, vitamin C, beta-carotene and selenium in patients with coronary heart disease may provide a prophylactic effect against oxidative stress.
MeSH Terms
-
alpha-Tocopherol
Antioxidants
Ascorbic Acid
beta Carotene
Catalase
Coronary Disease*
Erythrocytes
Glutathione Peroxidase
Humans
Lipid Peroxidation*
Oxidative Stress
Selenium
Superoxide Dismutase
Tocopherols
Vitamin A
Antioxidants
Ascorbic Acid
Catalase
Glutathione Peroxidase
Selenium
Superoxide Dismutase
Tocopherols
Vitamin A
alpha-Tocopherol
beta Carotene
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