Korean J Anesthesiol.  2005 Oct;49(4):477-483. 10.4097/kjae.2005.49.4.477.

The Effects of Perioperative Ketorolac Infusion on Platelet Function and Blood Loss: Comparison of Anesthesia Methods

• Choi YS
• Kim GS
• Min JH
• Lee JJ
• Chung IS

• KMID: 1936847
• DOI: http://doi.org/10.4097/kjae.2005.49.4.477

Abstract

BACKGROUND: The purposes of this study were to investigate the effects of perioperative continuous infusion of ketorolac on platelet function and blood loss under either general or spinal anesthesia.
METHODS
The patients under general anesthesia received saline 1 ml (C group) or ketorolac 30 mg (GK group) intravenously 10 min before skin incision, followed, respectively, by a continuous infusion of saline (4 ml/h) or ketorolac (2.5 mg/h) for 24 h. The patients under spinal anesthesia (SK group) received the same amount of ketorolac as that of the GK group. Blood loss was collected and measured at 3 h, 6 h, 12 h and 24 h postincision. Platelet count, hemoglobin, platelet aggregometry (PA) with adenosine diphosphate (ADP) and collagen, and bleeding time (BT) were measured at 30 min before skin incision and at 3 h and 24 h postincision. Blood coagulation status was analysed using thromboelastography (TEG) at 30 min before skin incision and at 3 h postincision.
RESULTS
BT in the SK group at postincision increased significantly compared to preoperative value and were significantly higher than those of the GK and C group. PA with collagen at 3 h after skin incision was lower in the SK group than in the C group. There were no significant differences in any of the TEG variables among the three groups. No significant differences were observed in blood loss among the three groups.
CONCLUSIONS
Blood loss was not increased by ketorolac under either general or spinal anesthesia, although platelet function was impaired under spinal anesthesia.

Keyword

blood loss; ketorolac; platelet function

MeSH Terms

Adenosine Diphosphate
Anesthesia*
Anesthesia, General
Anesthesia, Spinal
Bleeding Time
Blood Coagulation
Blood Platelets*
Collagen
Humans
Ketorolac*
Platelet Count
Skin
Thrombelastography
Adenosine Diphosphate
Collagen
Ketorolac