Korean J Anesthesiol.  2005 Nov;49(5):641-645. 10.4097/kjae.2005.49.5.641.

Effects of Adusted Dose of Local Anesthetic Considered Patient's Characteristics for Spinal Anesthesia for Elective Cesarean Section

• Lee C
• Son Y
• Yoon JS
• Cheong YK
• Kim MS

• KMID: 1936819
• DOI: http://doi.org/10.4097/kjae.2005.49.5.641

Abstract

BACKGROUND: Dosage influences distribution of a local anesthetic solution in cerebrospinal fluid. The dose of intrathecal local anesthetic was investigated, taking into account the patient's weight and height, to see whether this would stabilize the hemodynamics and provide adequate spinal anesthesia for Cesarean section.
METHODS
In this double-blind prospective study, 60 patients undergoing elective Caesarean delivery were randomized to receive either fentanyl 25microgram in hyperbaric 0.5% bupivacaine 2.5 ml (Group 1) or fentanyl 25microgram and 0.9% normal saline in a volume of hyperbaric 0.5% bupivacaine, taking into account the patient's weight and height (Group 2). The patient's hemodynamics, time to sugical incision, supplementary analgesia and conversion to general anesthesia, etc were recorded.
RESULTS
The incidence of hypotension and use of ephedrine were decreased, and the administration of fluid and the duration of motor blockade were significantly shorter in Group 2. The time to surgical incision was faster and the peak sensory level was higher in Group 1. Others effects were similar in both groups.
CONCLUSIONS
The dose of intrathecal local anesthetic, taking into account the patient's weight and height stabilized the hemodynamics and provided adequate spinal anesthesia for elective Cesarean section.

Keyword

Cesarean section; dose of local anesthetic; height; weight

MeSH Terms

Analgesia
Anesthesia, General
Anesthesia, Spinal*
Bupivacaine
Cerebrospinal Fluid
Cesarean Section*
Ephedrine
Female
Fentanyl
Hemodynamics
Humans
Hypotension
Incidence
Pregnancy
Prospective Studies
Bupivacaine
Ephedrine
Fentanyl