Korean J Anesthesiol.  1995 Mar;28(3):370-375. 10.4097/kjae.1995.28.3.370.

Salmon-Calcitonin; Analgesic Effect and Influence on the Morphine Induced Analgesia

• Leem JG

• KMID: 1934354
• DOI: http://doi.org/10.4097/kjae.1995.28.3.370

Abstract

Calcitonin is a peptide hormone involved primarily in the regulation of calcium homeostasis. However,clinical observations have shown that calcitonin does in fact possess an analgesic effect in a variety of painful disorders. So I studied the analgesic effect of intracerebroventricularly(i.c.v.) administered salmon calcitonin(s-CT) using the hot plate test and writhing test. The influence on the analgesia induced by morphine and naloxone reversibility was also studied. When s-CT was administered i.c.v., analgesia was observed in both tests,although it was greater in the writhing test than in the hot plate test. The analgesic effect of s-CT was partially but significantly reversed by naloxone. Thus, these results provide information about the antinociceptive effect of s-CT via interaction with both opiate and non-opiate mechanisms.

Keyword

salmon-Calcitonin; Morphine; Analgesia

MeSH Terms

Analgesia*
Calcitonin
Calcium
Homeostasis
Morphine*
Naloxone
Salmon
Calcitonin
Calcium
Morphine
Naloxone