Korean J Cytopathol.  2007 Sep;18(2):170-174.

Imprint Cytology of Granular Cell Tumor: A Case Report

• Sung WJ
• Choi JH

Abstract

Granular cell tumor is a rare tumor of the soft tissue and this is characterized by proliferation of large cells with granular appearing eosinophilic cytoplasm. We report the imprint cytologic features of a case of granular cell tumor in the left calf of a 52-year-old woman. Microscopic examination showed moderate cellularity. The tumor cells were arranged both as single cells and in clusters. The cells were large polygonal-shaped and they had small round nuclei with finely granular chromatin and occasionally conspicuous nucleoli. The cytoplasm was abundant eosinophilic and granular. Naked nuclei and spindle-shaped tumor cells were occasionally noted. No mitosis and necrosis were present. The background showed cytoplasmic granular materials. The tumor cells showed positivity for S-100 protein. Ultrastructurally, abundant lysosomes were present in the cytoplasm of the tumor cells.

Keyword

Granular cell tumor; Soft tissue; Cytology; Imprint

MeSH Terms

Chromatin
Cytoplasm
Eosinophils
Female
Granular Cell Tumor*
Humans
Lysosomes
Middle Aged
Mitosis
Necrosis
S100 Proteins
Chromatin
S100 Proteins