Korean J Cytopathol.  2008 Sep;19(2):200-205. 10.3338/kjc.2008.19.2.200.

Imprint Cytology of Hibernoma: A Case Report

Affiliations
  • 1Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea. joonhyukchoi@ynu.ac.kr
  • 2Department of Orthopedic Surgery, Yeungnam University College of Medicine, Daegu, Korea.

Abstract

Hibernoma is a rare, benign adipose tumor composed of brown fat cells with eosinophilic granular or multivacuolated cytoplasm. The cytologic features of hibernoma have been rarely reported and may mimic other polygonal cell neoplasms. We report the imprint cytologic features of a case of hibernoma in the left thigh of a 68-year-old woman. Microscopic examination showed large, round, or polygonal brown fat cells. The cells were arranged in fragments or clusters. The nuclei were uniformly round with finely granular chromatin. The cytoplasm was multivacuolated or univacuolated. The abundant eosinophilic granular cytoplasm was also present. No nuclear atypia were present. Immunohistochemical staining showed that cells were positive for S-100 protein.

Keyword

Hibernoma; Cytology

MeSH Terms

Adipocytes, Brown
Aged
Chromatin
Cytoplasm
Eosinophils
Female
Humans
Hydrazines
Lipoma
S100 Proteins
Thigh
Chromatin
Hydrazines
S100 Proteins
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