Korean J Otolaryngol-Head Neck Surg.
1997 Dec;40(12):1858-1862.
A Case of Giant Keratoacanthoma of the Lower Lip Treated with Intralesional Methotrexate
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- 1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Inje University, Pusan, Korea.
Abstract
- Keratoacanthoma(KA) is a rapidly growing benign cutaneous neoplasm, usually occurring on sunexposed sites in elderly people, and it has a close clinical and pathologic resemblance to squamous cell carcinoma. Giant KA of the lower lip is extremely rare. Various treatment modalities have been reported including radiation therapy, systemic oral retinoids, and the intralesional application of 5-fluorouracil(5-FU), methotrexate(MTX) or interferon alpha-2a. Excisional surgery, however, remains the treatment of choice for the majority of KA. The disadvantages of excision are the possible requirement for extensive reconstructive surgery and the resultant cosmetic or functional deficit. Recently, we experienced a case of giant KA of the lower lip in a 60-year-old male, and he was treated successfully with intralesional methotrexate. Now we report the case with a brief review of literature.
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