Korean J Dermatol.  2002 May;40(5):555-558.

Successful Treatment of Two Cases of Keratoacanthomas with Intralesional Methotrexate

• You DO
• Youn NH
• Park SD

Abstract

Keratoacanthoma is a rapidly growing tumor that has the tendency of spontaneous involution but it may persist for some times, continue to enlarge and may become invasive and destructive. Many modalities are available for the treatment of keratoacanthoma. Although excisional surgery is the treatment of choice, this can result in functional and cosmetic defects when large or strategically located lesions are treated. An effective nonsurgical treatment would be desirable in such cases. We report two cases with unusually large or facial keratoacanthoma treated with intralesional methotrexate. One case showed complete resolution over 6 injections and the other after 2 injections. We suggest that intralesional injection of methotrexate is a simple, effective, safe and inexpensive method for the treatment of large keratoacanthoma.

Keyword

Keratoacanthoma; Methotrexate

MeSH Terms

Injections, Intralesional
Keratoacanthoma*
Methotrexate*
Methotrexate