Korean J Thorac Cardiovasc Surg.
2007 Apr;40(4):305-308.
Restoration of Blood Pressure after Administering Methylene Blue for Vasoplegic Syndrome, which Developed after Open Heart Surgery for Septic Infective Endocarditis: A case report
- Affiliations
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- 1Department of Thoracic and Cardiovascualr Surgery, Severance Hospital, Yonsei University College of Medicine, Korea. dkkim0327@hanmail.net
Abstract
- Vasoplegic syndrome occurs in 8~10% of patients following cardiac surgery, and this happens in part because of inducing the inflammatory response. Nitric oxide and guanylate cyclase play an important role in this response, and this is associated with increased morbidity and mortality. For our case, we administered methylene blue (MB), an inhibitor of guanylate cyclase, early after performing cardiopulmonary bypass in a patient with vasoplegic syndrome. The patient recovered immediately after MB administration and maintained an optimal blood pressure without the aid help of any vasopressors.
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