Korean J Thorac Cardiovasc Surg.  2007 Apr;40(4):273-279.

Blood Protein Adsorption and Platelet Activation on an Ultra-hydrophilic Substrate

• Park NH
• Chun BH
• Je HG
• Lee JW
• Lee JW

Abstract

BACKGROUND: We evaluate the efficacy of ultra-hydrophilic coated bypass circuits in comparison with uncoated bypass circuits in a porcine cardiopulmonary bypass model. MATERIAL AND METHOD: Normothermic cardiopulmonary bypass was performed in 10 anesthetized pigs via the left atrium and ascending aorta with a centrifugal biopump. Ultra-hydrophilic coated bypass circuits were used in 5 pigs (the study group) and uncoated bypass circuits were used for the control group. Platelet counts and platelet aggregation tests were performed. The thrombin-antithrombin (TAT) complex level and total protein level were evaluated. RESULT: There were no significant changes in the platelet counts and aggregation ability of both groups. The TAT complex levels were not different between the two groups. The total protein level was significantly lower in the control group after cessation of cardiopulmonary bypass.
CONCLUSION
The clinical effects of ultra-hydrophilic coating circuits were not remarkable, in terms of reducing inflammatory reaction and protection of platelet function. However, the effect of protection for blood protein adsorption might be acceptable.

Keyword

Cardiopulmonary bypass, inflammatory response

MeSH Terms

Adsorption*
Aorta
Blood Platelets*
Cardiopulmonary Bypass
Heart Atria
Platelet Activation*
Platelet Aggregation
Platelet Count
Swine