J Korean Breast Cancer Soc.  2003 Mar;6(1):8-14. 10.4048/jkbcs.2003.6.1.8.

Translational Regulation: A Novel Target for Breast Cancer Therapy

• Noh WC
• Paik NS

• KMID: 1906252
• DOI: http://doi.org/10.4048/jkbcs.2003.6.1.8

Abstract

Translational initiation is regulated in response to nutrient availabilty and growth stimuli and is coupled with cell cycle progression and cell growth. There is now growing body of evidence which suggests links between translational regulation and the disruption of cell behavior that results in the development and progression of cancer. mRNA translation can be overactivated in breast cancer through eIF4E overexpression or abnormal activation of signal transduction pathways. Among them, rapamycin-sensitive signal transduction pathway (mTOR signaling pathway) is now being studied as a novel target for cancer therapy. In this article, the basic principles of translational control, the alterations encountered in cancer and selected therapy targeting mTOR signaling pathway are reviewed and the preclinical study regarding the determinants of rapamycin sensitivity in breast cancer is presented in order to help elucidate new avenues for breast cancer therapy.

Keyword

Translation initiation; mTOR signaling pathway; Breast cancer

MeSH Terms

Breast Neoplasms*
Breast*
Cell Cycle
Eukaryotic Initiation Factor-4E
Protein Biosynthesis
Signal Transduction
Sirolimus
Eukaryotic Initiation Factor-4E
Sirolimus