Korean J Anat.  2003 Feb;36(1):31-38.

Changes of the Cholinergic Innervation to the Hippocampus after Entorhinal Cortex Lesion in Rat

• Ko MH
• Kim DS
• Byun KH
• Kim JW
• Kim MJ
• Oh MY
• Lee BH

Abstract

The hippocampus is known as involved in learning and memory functions and the entorhinal cortex plays a crucial role as a gateway connecting the several areas and hippocampal formation. Entorhinal cortex lesions have been employed in numerous studies as the Alzheimer's disease model. The purpose of this study were to identify the CNS hip-pocampal and cholinergic pathway and to investigate the morphological changes of the hippocampal cholinergic inner-vations by using the Pseudorabies virus injection into the hippocampus after entorhinal cortex lesions. The pseudorabies virus and double labelled neurons (ChAT and PRV) were distributed at several different nuclei including agranular insular cortex, bed nucleus of stria terminalis, central amygdala, globus pallidus, lateral segment, lateral hypothalamic area, laterodorsal tegmental nucleus, medial septal nucleus, mesencephalic reticular nucleus, periaqueductal gray matter and substantia innominata The morphological changes were observed in the hippocampal cholinergic innervation after entorhinal cortex lesions. These data suggested that the hippocampal cholinergic innervation showed morphological changes throughout the whole brain areas after entorhinal cortex lesion.

Keyword

Hippocampus; Pathway; Pseudorabies virus; Entorhinal cortex lesion; Cholinergic

MeSH Terms

Alzheimer Disease
Amygdala
Animals
Brain
Entorhinal Cortex*
Globus Pallidus
Herpesvirus 1, Suid
Hippocampus*
Hypothalamic Area, Lateral
Learning
Memory
Neurons
Periaqueductal Gray
Rats*
Septal Nuclei
Substantia Innominata